Infertility: Causes, Diagnosis & Treatment

Written By: Dr. Peter Nawar

Updated On:January 26, 2025

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What is Infertility?

An issue with your reproductive system called infertility prevents people from being able to conceive. There are numerous causes of infertility, which can affect anyone. Pregnancy involves a number of steps:

  • Reproductive hormones that regulate ovarian function are produced by the brain.
  • Your ovary must allow an egg to develop.
  • Ovulation, the release of an egg, is required.
  • The egg needs to be taken up by your fallopian tube.
  • In order to reach your fallopian tube, sperm must ascend your vagina and pass through your uterus.
  • An embryo is created when the sperm fertilizes the egg.
  • Your fallopian tube transports the embryo to your uterus, where it implants.
  • If any step in this procedure doesn't take place, a pregnancy cannot happen.

Having regular, unprotected intercourse is referred to as trying to get pregnant. After a year (12 months) of trying to get pregnant, your doctor may diagnose infertility if you're under 35. After six months of frequent, unprotected sex, your doctor may diagnose infertility if you are 35 years old or older.

It happens more frequently than you might imagine. For those who want to have or grow a family, there are fortunately several treatment choices accessible.

Types of Infertility

The following are types of infertility:

  • Primary infertility is the inability to conceive after a year (or six months if you are 35 or older) of regular, unprotected sexual activity if you have never become pregnant.
  • Secondary infertility: After at least one successful pregnancy, you are unable to become pregnant again.
  • Undiagnosed infertility: A person's or a couple's inability to become pregnant has not been explained by fertility tests.

Causes of Infertility

There are many reasons why people experience infertility, and there may not always be a clear explanation. The cause and the ideal course of treatment for you can only be found by a healthcare professional.

Infertility might be a result of concerns with the uterus or ovaries, concerns with the penis and testicles, or concerns with both partners. Infertility might also not have a defined cause.  

Signs and Symptoms of Infertility

Being unable to become pregnant after six or a year of regular, unprotected intercourse is the primary indicator of infertility. It's possible that you are symptom-free. However, some individuals may display bodily signs like:

  • Abdominal or pelvic discomfort
  • Irregular periods, irregular vaginal bleeding, or no periods at all
  • Ejaculatory diseases or problems with the penile

When to see a doctor for Infertility?

A healthcare professional should be consulted by those under 35 who have tried for a year and have not become pregnant. If you're between the ages of 35 and 39, you should get help sooner (after trying for six months). After less than six months of attempting, those who are 40 years of age or older should get evaluated.

Infertility Risk Factors

While some infertility causes impact only one partner, others affect both. Among the risk factors for infertility are:

  • As a female, being in your late 30s or early 40s
  • Nearer to 50 is when men's fertility starts to decline due to aging
  • Bulimia and other eating disorders, such as anorexia nervosa
  • Excessive alcoholism
  • Exposure to environmental pollutants, such as pesticides, chemicals, and lead
  • Over-exercising
  • The use of chemotherapy or radiation
  • STIs, or sexually transmitted infections
  • Consuming tobacco and smoking
  • Overuse of drugs
  • Either being overweight or obese
  • Abnormalities in your brain's hypothalamus or pituitary, which both produce hormones
  • Chronic ailments and illnesses

Infertility Complications

Treatment for infertility can be complicated by twins, triplets, or more multiple births, OHSS, or ovarian hyperstimulation syndrome, ectopic pregnancy, and failed cycles. 

Infertility Diagnosis

Diagnosis for Female Infertility

Your healthcare physician will first ask you about your whole medical and sexual history.

The ovulation of healthy eggs is a requirement for fertility in those with uteruses. This implies that in order for an egg to be released from your ovary, travel down your fallopian tube, and land on the lining of your uterus, your brain must transmit hormonal signals to your ovary. The goal of fertility testing is to identify a problem with any of these processes.

Additionally, these tests may be used to identify or rule out issues:

  • A pelvic exam to look for structural issues or illness symptoms
  • Blood tests to determine whether you are ovulating
  • Transvaginal ultrasound to check for reproductive system problems.
  • Hysteroscopy to examine your uterus
  • The use of saline sono-hysterogram (SIS) or sono-hysterosalpingogram (HSG) to look for tubal obstructions
  • X-ray hysterosalpingogram (HSG) to look for blockage
  • Laparoscopy to detect issues of concern, such as scar tissue, uterine fibroids, and endometriosis.

Diagnosis for Male Infertility

Verifying that a person produces healthy sperm in their ejaculate is often necessary to diagnose infertility in those with a penis. Most fertility tests search for sperm issues.

These tests can aid in problem diagnosis or problem exclusion:

  • Analyzing the semen: This test looks for low sperm counts and poor sperm motility. To collect sperm from their testicles for testing, some persons require a needle biopsy.
  • Checking thyroid and other hormone levels with a blood test. During genetic blood tests, defective chromosomes are sought after.
  • Scrotal ultrasound: A scrotal ultrasound can detect varicoceles or other testicular issues.

Infertility Treatment

Female Infertility Treatment

Women and those born with the gender assigned can receive the following treatments for infertility:

  • Changes in lifestyle might increase your chances of getting pregnant, including gaining or decreasing weight, quitting smoking or using drugs, and addressing other medical conditions.
  • Medication: Fertility medications encourage your ovaries to release more eggs from your ovaries, increasing your likelihood of becoming pregnant.
  • Surgery: Surgery can free clogged fallopian tubes and get rid of scar tissue, polyps, and fibroids.

Male Infertility Treatment

If you have a penis or testes, you can have reproductive treatments like:

  • Medication: Medication can increase the levels of testosterone or other hormones. To assist you keep an erection during sexual activity, there are also medications for erectile dysfunction.
  • Surgery: Some men require surgery to clear obstructions in the sperm canals or to fix structural issues. The chances of conception are increased with varicocele surgery by improving the health of sperm.

Other Treatments for Infertility

Some couples require extra assistance while utilizing assisted reproductive technologies to get pregnant. Before attempting one of these techniques, you can take drugs to promote ovulation to boost your chances of becoming pregnant. These include in-vitro fertilization (IVF), Intracytoplasmic sperm injection (ICSI), Intrauterine insemination (IUI), assisted hatching, and third-party assisted reproductive technology, such as the use of donor eggs, sperms, or embryos or even a surrogate.

Infertility Prevention

The following actions can be taken to preserve your fertility, particularly while attempting to conceive:

  • Eat a balanced diet and keep your weight at a healthy level.
  • Avoid using drugs, smoking, or consuming alcohol.
  • Receive STI treatment.
  • Be careful not to overexpose yourself to poisons.
  • Continue to be physically active, but don't overdo it.
  • Don't wait too long to get pregnant.
  • Sperm or egg freezing treatments to preserve fertility.

References

Balasch, J. (2010). Ageing and infertility: an overview. Gynecological Endocrinology26(12), 855-860.

Balen, A. H., & Rutherford, A. J. (2007). Management of infertility. Bmj335(7620), 608-611.

Carson, S. A., & Kallen, A. N. (2021). Diagnosis and management of infertility: a review. Jama326(1), 65-76.

Leaver, R. B. (2016). Male infertility: an overview of causes and treatment options. British Journal of Nursing25(18), S35-S40.

Smith, S., Pfeifer, S. M., & Collins, J. A. (2003). Diagnosis and management of female infertility. Jama290(13), 1767-1770.

Templeton, A. (2000). Infertility and the establishment of pregnancy–overview. British medical bulletin56(3), 577-587.

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